eComment. Gender mismatching in lung transplantation: lung size mismatch is the issue!

30-day mortality, PGD, BOS and long-term survival. Although we aimed at constructing a homogeneous study group (adjusting for size and diagnosis), other confounding factors might have had an influence. These circumstances might have biased the results to some degree but not, in our opinion, to an extent that may invalidate the main conclusions drawn from the study. To summarize, this single-centre, retrospective analysis found that D/R gender mismatch does not have a negative impact on short-term and long-term outcomes after lung transplantation. The survival benefit for female patients might be associated with the predominance of CF in this particular group of recipients. Therefore, gender should not be considered a significant enough issue in considering the way the lungs are allocated, because of the constraints of shortage of donor organs and the more significant effects of other donor factors including age and underlying disease. For these reasons, D/R gender matching should not be taken into consideration when allocating donors to specific lung transplant candidates. Additional investigations are required to corroborate these results. Role of gender and race mismatch and graft failure in patients undergoing liver transplantation. Donor-recipient gender and size mismatch affects graft success after kidney transplantation.recipient gender mis-match in lung transplantation: impact on obliterative bronchiolitis and survival. Influence of donor characteristics on outcome after lung transplantation: a multicenter study. effect of gender combinations on outcome in human lung transplant-ation: the International Society of Heart and Lung Transplantation Registry experience. Transplantation: twenty-eighth adult lung and heart-lung transplant report—2011. gender hormones regulate mRNA levels and function of the rat lung epi-thelial Na channel. et al. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. Influence of donor-recipient gender mismatch in early outcome after lung transplantation. JR et al. Clinical risk factors for primary graft failure following lung trans-plantation. et al. Validation of the proposed International Society for Heart and Lung Transplantation grading system for primary graft dysfunction after lung transplantation. We read with great interest the study by Alvarez et al. on gender mismatched lung transplantation (LTx) and clinical outcomes [1]. We agree with the authors' conclusion that donor-recipient gender mismatch does not have a negative impact on early graft function and mortality following LTx. However, we would like to use this comment to expand on the rationale. Gender is a major determinant of lung size, together with height (age and race) [2]. Lung size can be estimated by the predicted total …